By Gerald F. Combs Jr. (Author)
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Extra resources for The Vitamins, Third Edition Hardcover
He noted that, whereas the disease was prevalent among the inmates it was absent among the staff, including the nurses and physicians who cared for patients; this suggested to him that pellagra was not an infectious disease. Noting that the food available to the professional staff was much different from that served to the inmates (the former included meat and milk not available to the inmates), Goldberger suspected that an unbalanced diet was responsible for the disease. He secured funds to supply meat and milk to inmates for a two-year period of study.
J. Williams was pursuing studies of the essential nutrients for Saccharomyces cerevisiae and other yeasts. 32 Nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP), respectively. ” 32 The first isolation of pantothenic acid employed 250 kilograms of sheep liver. The autolysate was treated with fuller’s earth; the factor was adsorbed to Norite and eluted with ammonia. Brucine salts were formed and were extracted with chloroform–water, after which the brucine salt of pantothenic acid was converted to the calcium salt.
4 Casal practiced in the town of Oviedo in the Asturias of northern Spain. 12 Discovery of the Vitamins from George Searcy’s 1907 report to the American Medical Association that the disease was endemic at least in Alabama. By 1909, it had been identified in more than 20 states, several of which had empaneled Pellagra Commissions, and a national conference on the disease was held in South Carolina. Since it first appeared, pellagra was associated with poverty and with the dependence on corn as the major staple food.