The Nuclear Receptor Facts: Book by Vincent Laudet and Hinrich Gronemeyer (Auth.)

By Vincent Laudet and Hinrich Gronemeyer (Auth.)

The FactsBook Series has validated itself because the most sensible resource of simply obtainable and actual proof approximately protein teams. They use an easy-to-follow layout and are researched and compiled through specialists within the field.
This Factsbook is dedicated to nuclear receptors. the 1st part provides an creation and describes the mode of motion of the receptors generally. the second one component of the booklet comprises exact entries overlaying each one kind of receptor.

Entries offer details on:
Nomenclature and structure
Isolation
DNA binding properties
Ligands
Expression
Target genes
Knockouts
Disease organization
Gene constitution, promoter and isoforms
Chromosomal location
Amino acid sequences
Key references

Show description

By Vincent Laudet and Hinrich Gronemeyer (Auth.)

The FactsBook Series has validated itself because the most sensible resource of simply obtainable and actual proof approximately protein teams. They use an easy-to-follow layout and are researched and compiled through specialists within the field.
This Factsbook is dedicated to nuclear receptors. the 1st part provides an creation and describes the mode of motion of the receptors generally. the second one component of the booklet comprises exact entries overlaying each one kind of receptor.

Entries offer details on:
Nomenclature and structure
Isolation
DNA binding properties
Ligands
Expression
Target genes
Knockouts
Disease organization
Gene constitution, promoter and isoforms
Chromosomal location
Amino acid sequences
Key references

Show description

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M. et al. (1992) Mol. Endocrinol. 6, 429-442. K. (1987) Nature 329, 738-741. K. et al. (1988) Cell 54, 313-323. 45 Sap, J. et al. (1989) Nature 340, 242-244. L. and Morkin, E. (1990) J. Biol. Chem. 265, 11233-11237. 47 Izumo, S. and Mahdavi, V. (1988) Nature 334, 539-542. 48 Desvergne, B. et al. (1991) J. Biol. Chem. 266, 1008-1013. W. J. (1993) J. Biol. Chem. 268, 19392-19397. 50 Zechel, C. et al. (1994) EMBO J. 13, 1425-1433. 5^ Zechel, C. et al. (1994) EMBO J. 13, 1414-1424. ^^ Farsetti, A. (1992) J.

TRs also exhibit a preferred spacing for inverted palindromes of six nucleotides (myelin basic protein^^). Inverse TREs The existence of a peculiar type of transcription in the absence and repress similar mechanism has been proposed Note, however, that the existence of ligands cannot be rigorously excluded considered as agonistic ligands for CARp TRE has been reported^'''^* to activate transcription in the presence of ligand. A for the former orphan receptor CARp^^. endogenous or serum-derived agonistic in these cases,- this notion has to be have also been reported to exist^^.

37 Berry, M . et al. (1990) E M B O J. 9, 2 8 1 1 - 2 8 1 8 . A. et al. (1994) Mol. Endocrinol. 8, 1347-1360. 39 Guiochon-Mantel, A. et al. (1994) Proc. Natl Acad. Sci. USA 91, 7179-7183. T. et al. (1999) Cell Biochem. Biophys. 31, 119-127. J. W. (1994) Annu. Rev. Biochem. 63, 451-486. "^^ Moras, D. and Gronemeyer, H. (1998) Curr. Opin. Cell Biol. 10, 384-391. ^^ Bourguet, W. et al. (1995) Nature 375, 377-382. P. et al. (1995) Nature 378, 681-689. L. et al. (1995) Nature 378, 690-697. M. et al.

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