The Isoquinoline Alkaloids: Chemistry and Pharmacology by Maurice Shamma

By Maurice Shamma

The Isoquinoline Alkaloids: Chemistry and Pharmacology offers an summary of the chemistry, biogenesis, spectroscopy, and pharmacology of the isoquinoline alkaloids. This booklet examines the numerous and engaging facets of alkaloids.
Organized into 32 chapters, this e-book begins with a dialogue of the biogenesis of the isoquinolines and many of the pharmacological results of easy tetrahydroisoquinolines that experience stimulant and convulsive houses. this article then explores the infrared absorptions, with emphasis on wavelength and frequency. different chapters contain issues on synthesis, degradation, reactions, absolute configuration, in addition to on ultraviolet and nuclear magnetic resonance spectroscopy. This booklet additional explores a number of the equipment to be had for the coaching of easy tetrahydroisoquinolines, together with the Bischler–Napieralski, Pictet–Spengler, and phenolic cyclization, in addition to the Friedel–Crafts acylation. The final bankruptcy bargains with ancistrocladine, that is the 1st isoquinoline alkaloid chanced on to own a methyl workforce.
Biochemists and biophysicists will locate this ebook necessary.

Show description

By Maurice Shamma

The Isoquinoline Alkaloids: Chemistry and Pharmacology offers an summary of the chemistry, biogenesis, spectroscopy, and pharmacology of the isoquinoline alkaloids. This booklet examines the numerous and engaging facets of alkaloids.
Organized into 32 chapters, this e-book begins with a dialogue of the biogenesis of the isoquinolines and many of the pharmacological results of easy tetrahydroisoquinolines that experience stimulant and convulsive houses. this article then explores the infrared absorptions, with emphasis on wavelength and frequency. different chapters contain issues on synthesis, degradation, reactions, absolute configuration, in addition to on ultraviolet and nuclear magnetic resonance spectroscopy. This booklet additional explores a number of the equipment to be had for the coaching of easy tetrahydroisoquinolines, together with the Bischler–Napieralski, Pictet–Spengler, and phenolic cyclization, in addition to the Friedel–Crafts acylation. The final bankruptcy bargains with ancistrocladine, that is the 1st isoquinoline alkaloid chanced on to own a methyl workforce.
Biochemists and biophysicists will locate this ebook necessary.

Show description

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Sih, J. Org. Chem. 33, 856 (1968). 22. D. W. Brown, S. F. Dyke, and M. Sainsbury, Tetrahedron 25, 101 (1969). 23. G. Gfethe, H. L. Lee, M. Uskokovic, and A. Brossi, J. Org. Chem. 33, 491 and 494 (1968). 24. For a related synthesis, see B. Umezawa, O. Hoshino, and Y. Terayama, Chem. Pharm. Bull. 16, 180 (1968). 25. I. G. Hinton and F. G. Mann, J. Chem. Soc, London p. 599 (1959). 26. B. Jaques, R. H. L. Deeks, and P. K. J. Shah, Chem. Commun. p. 1283 (1969). 27. D. N. Harcounfrand R. D. Waigh, Chem.

Latericine Preininger and co-workers have investigated the structure and stereochemistry of the alkaloid (-f)-latericine, C 2 4H 2 9 N 0 8 , which was obtained in small yields from a 11 variety of Papaver species. Hydrolysis of latericine with sulfuric acid gave an aglycone which was characterized as (+)-7-demethylarmepavine, while the sugar moiety corresponded to D-( + )-xylose. O-Methylation of latericine with diazomethane and subsequent hydrolysis of the product gave the aglycone L-( + )-N,0-dimethylcocla urine, thus fixing the position of the glycoside moiety in the alkaloid (Scheme I V ) .

L. Smith, R. O. C. Norman, and J. S. Sadd, Chem. Commun. p. 1116 (1969). 28a. J. R. L. Smith, R. O. C. Norman, and A. G. Rowley, Chem. Commun. p. 1238 (1970). 29. D. M. Ziegler and F. H. Pettit, Biochem. Biophys. Res. Commun. 15, 188 (1964). 30. J. P. Ferris, R. D. Gerwe, and G. R. Gapski, J. Amer. Chem. Soc. 89, 5270 (1967). 31. A. R. Battersby, Proc. Chem. Soc, London p. 189 (1963). 32. J. Finkelstein and A. Brossi, J. Heterocycl. Chem. 4, 315 (1967). 33. G. Rosen and F. D. Popp, Can. J. Chem.

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