Ciba Foundation Symposium - Chemistry and Biology of Purines by G. E. W. and O'Connor, Cecilia M. Wolstenholme

By G. E. W. and O'Connor, Cecilia M. Wolstenholme

Content:
Chapter 1 starting feedback (pages 1–2):
Chapter 2 Synthesis and homes of Purines of power organic curiosity (pages 3–19): Aaron Bendich, Alfredo Giner?Sorolla and Jack J. Fox
Chapter three a few man made stories on Purines and similar Heterocycles (pages 20–38): E. C. Taylor, T. S. Osdene, E. Richter and O. Vogl
Chapter four a few New N?Methylpurines (pages 39–49): Gertrude B. Elion
Chapter five The constitution of the Hydroxypurines Investigated via O? and N?Methylation (pages 50–59): D. J. Brown
Chapter 6 The Spectra and constitution of the Monohydroxypurines and different possibly Tautomeric Purines (pages 60–71): S. F. Mason
Chapter 7 The ??Electron homes of Purine Calculated by way of the L.C.A.O. technique (pages 72–76): S. F. Mason
Chapter eight The Degradation of Uric Acid by means of Water stressed (pages 77–96): Wolfgang Pfleiderer
Chapter nine The 8?Position in Purines. The Chemical and organic Transformation of Purines Into Pteridines (pages 97–107): Adrien Albert
Chapter 10 Cyclonucleosides (pages 108–119): D. M. Brown, Sir Alexander Todd and S. Varadarajan
Chapter eleven Stereochemistry of Nucleoside Synthesis (pages 120–133): B. R. Baker
Chapter 12 man made Chemical Investigations with regards to the Metabolism of Purines (pages 134–145): G. M. Timmis, I. Cooke and R. G. W. Spickett
Chapter thirteen the consequences of strength Antipurines on a Purine?Requiring pressure of Escherichia coli (pages 146–159): H. O. J. Collier and Patricia L. Huskinson
Chapter 14 The Chemistry of recent Purines within the B (pages 160–168): E. Lester Smith
Chapter 15 organic and Microbiological job of Purine Analogues of diet B (pages 169–176): S. ok. Kon
Chapter sixteen Puromycin (pages 177–191): Brian L. Hutchings
Chapter 17 Chemical and organic Behaviours of 9???d?Ribofuranosylpurine (pages 192–203): G. B. Brown, M. P. Gordon, D. I. Magrath and A. Hampton
Chapter 18 at the Activation of the One?Carbon Unit for the Biosynthesis of Purine Nucleotides (pages 204–232): G. Robert Geeenberg and Lothar Jaenicke
Chapter 19 The Enzymatic Synthesis of Inosinic Acid De Novo (pages 233–255): J. M. Buchanan, J. G. Flaks, S. C. Hartman, B. Levenberg, L. N. Lukens and L. Warren
Chapter 20 Enzymic keep watch over of Purines by way of Xanthine Oxidase (pages 256–269): F. Bergel, R. C. Bray, A. Haddow and that i. Lewin
Chapter 21 The organic results of 8?Azapurines (pages 270–285): R. E. F. Matthews
Chapter 22 Biochemical results of 6?Mercaptopurine (pages 286–308): Gertrude B. Elion and George H. Hitchings
Chapter 23 using 6?Mercaptopurine within the therapy of Leukaemia (pages 299–307): D. A. G. Galton
Chapter 23 normal dialogue (pages 308–317):

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By G. E. W. and O'Connor, Cecilia M. Wolstenholme

Content:
Chapter 1 starting feedback (pages 1–2):
Chapter 2 Synthesis and homes of Purines of power organic curiosity (pages 3–19): Aaron Bendich, Alfredo Giner?Sorolla and Jack J. Fox
Chapter three a few man made stories on Purines and similar Heterocycles (pages 20–38): E. C. Taylor, T. S. Osdene, E. Richter and O. Vogl
Chapter four a few New N?Methylpurines (pages 39–49): Gertrude B. Elion
Chapter five The constitution of the Hydroxypurines Investigated via O? and N?Methylation (pages 50–59): D. J. Brown
Chapter 6 The Spectra and constitution of the Monohydroxypurines and different possibly Tautomeric Purines (pages 60–71): S. F. Mason
Chapter 7 The ??Electron homes of Purine Calculated by way of the L.C.A.O. technique (pages 72–76): S. F. Mason
Chapter eight The Degradation of Uric Acid by means of Water stressed (pages 77–96): Wolfgang Pfleiderer
Chapter nine The 8?Position in Purines. The Chemical and organic Transformation of Purines Into Pteridines (pages 97–107): Adrien Albert
Chapter 10 Cyclonucleosides (pages 108–119): D. M. Brown, Sir Alexander Todd and S. Varadarajan
Chapter eleven Stereochemistry of Nucleoside Synthesis (pages 120–133): B. R. Baker
Chapter 12 man made Chemical Investigations with regards to the Metabolism of Purines (pages 134–145): G. M. Timmis, I. Cooke and R. G. W. Spickett
Chapter thirteen the consequences of strength Antipurines on a Purine?Requiring pressure of Escherichia coli (pages 146–159): H. O. J. Collier and Patricia L. Huskinson
Chapter 14 The Chemistry of recent Purines within the B (pages 160–168): E. Lester Smith
Chapter 15 organic and Microbiological job of Purine Analogues of diet B (pages 169–176): S. ok. Kon
Chapter sixteen Puromycin (pages 177–191): Brian L. Hutchings
Chapter 17 Chemical and organic Behaviours of 9???d?Ribofuranosylpurine (pages 192–203): G. B. Brown, M. P. Gordon, D. I. Magrath and A. Hampton
Chapter 18 at the Activation of the One?Carbon Unit for the Biosynthesis of Purine Nucleotides (pages 204–232): G. Robert Geeenberg and Lothar Jaenicke
Chapter 19 The Enzymatic Synthesis of Inosinic Acid De Novo (pages 233–255): J. M. Buchanan, J. G. Flaks, S. C. Hartman, B. Levenberg, L. N. Lukens and L. Warren
Chapter 20 Enzymic keep watch over of Purines by way of Xanthine Oxidase (pages 256–269): F. Bergel, R. C. Bray, A. Haddow and that i. Lewin
Chapter 21 The organic results of 8?Azapurines (pages 270–285): R. E. F. Matthews
Chapter 22 Biochemical results of 6?Mercaptopurine (pages 286–308): Gertrude B. Elion and George H. Hitchings
Chapter 23 using 6?Mercaptopurine within the therapy of Leukaemia (pages 299–307): D. A. G. Galton
Chapter 23 normal dialogue (pages 308–317):

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1937). Bull. chim. ,(5),4,854. ,, TODD,A. , and TOPHAM, A. (1943). KENNER,G. , LYTHGOE, J . chem. ,574. MOHR,E. (1909). J. prakt. , 79, 1. SHAW, E. (1950). J . biol. , 185, 439. TAYLOR, E. , CARBON, J. A,, and HOFF, D. R. (1953). J. Amer. chem. SOC;,75, igos. E. , GARLAND, R. , and HOWELL,C. F. (1956). J. Amer. TAYLOR, chem. ,78, 210. DISCUSSION Schmidt: In the course of our studies on the heterocyclic series, under the direction of Dr. Druey, we too were concerned with structural analogues of purines as possible antimetabolites.

The remarkable thing is that the animal dies with merely a little oedema, a little haemorrhage before death. There is no specific localized pathology which anyone can quote to us. Recently Dr. Philips and Dr. Bodansky have investigated a test that Bodansky has been conducting, which is the level of phosphohexose isomerase in the blood; 6-methylpurine increases this greatly, possibly by liver damage and release of the enzymes from the liver. Collier: This toxicity might differ in time-course from those of strychnine and morphine, which Prof, Albert mentioned.

Chem. , 30, 2226. FISCHER, E. (1897b). Ber. dtsch. chem. , 30, 2400. FISCHER, E. Ber. dtsch. chem. , 31, 104. FISCHER, E. (18983). Ber. dtsch. chem. , 31, 431. FISCHER, E. Ber. dtsch. chem. , 31,542. GELLHORN, A,, and HIRSCHBERG, E. (1955). , 3, 1. HITCHINGS, G. , and ELION,G. B. (1955). Confkrences et Rapports, I11 Int. Congr. , 55. HITCHINGS, G. , and FALCO, E. A. (1944). Proc. nut. Acad. , 30,294. HITCHINGS, G. , and RHOADS, C. P. (1954). Ann. N . Y . Acad. ,60, art. 2. HOTCHKISS, R. (1948).

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