By Guoan Luo, Yiming Wang, Qionglin Liang, Qingfei Liu
The software of platforms biology easy methods to conventional chinese language Medicine
Emphasizing the concord of the human physique with the surroundings, conventional chinese language medication (TCM) has developed over hundreds of thousands of years. it's a systemic idea derived from scientific event, the philosophy of holism and systematology, and the assumption that guy is a vital part of nature.
Systems Biology for standard chinese language Medicine describes how the newest tools in platforms biology could be utilized to TCM, delivering a entire source for the modernization and development of TCM in addition to basic drug discovery efforts. it's the first entire paintings to suggest a system-to-system learn technique to check the interplay among TCM and the human physique and its purposes in drug learn and development.
Using 3 renowned conventional chinese language medicines?Shuanglongfang, Qingkailing, and Liushenwan?as examples, the authors set forth case examples demonstrating how to define fabric teams, practice efficacy screenings, and behavior safeguard reviews of TCM. The e-book also:
- Describes the mechanisms of TCM on the molecular and platforms degrees utilizing chemomics, genomics, proteomics, metabolomics, and bioinformatics
- Places sleek clinical applied sciences in the context of TCM, assisting drug researchers enhance experimental designs and strategies
- Illustrates how a structures biology technique is appropriate with TCM's conventional, holistic healing recommendations and remedy modalities
- Presents subject matters of present curiosity, akin to built-in international platforms biology and the appliance of chemometrics learn to natural medicines
This publication not just opens a brand new pathway for the continuing improvement of TCM, but additionally for platforms biology. moreover, it fosters collaboration and dialogue between japanese and Western scientists by way of utilizing structures biology to TCM.
Chapter 1 advent of structures Biology in conventional chinese language drugs (TCM) (pages 1–37):
Chapter 2 Chemomics of conventional chinese language medication (pages 38–65):
Chapter three Technological Platform of TCM Chemomics (pages 66–130):
Chapter four Pharmacokinetic research on TCM formulation in keeping with international structures Biology (pages 131–145):
Chapter five software of Genomics within the examine of TCM (pages 146–170):
Chapter 6 Proteomics examine of TCM (pages 171–190):
Chapter 7 program of Metabonomics in study on TCM (pages 191–209):
Chapter eight program of Chemometrics and Bioinformatics in TCM study (pages 210–227):
Chapter nine examine of built-in Biomarker method of Diabetic Nephropathy (pages 228–316):
Chapter 10 Chemomics learn at the TCM formulation of the Qingkailing Injection (pages 317–370):
Chapter eleven built-in international platforms Biology for the learn and improvement of chinese language drugs Shuanglong formulation (pages 371–436):
Chapter 12 Demonstrative study at the security assessment of Liushen capsules (pages 437–480):
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Additional info for Systems Biology for Traditional Chinese Medicine
Tissue chips are mainly used in research on high-throughput pharmacology, toxicology, and pathology. Phenomics is the terminal of the omics platform for systems biology, implementing the whole process for genome sequence to basic vital activities by genomics, transcriptomics, proteomics, metabonomics, interactomics, and phenomics. Systematic investigations from genomics to phenomics have been conducted in the glycometabolism of colibacillus and yeast. More and more cell chips have been used for the discovery of new medicines and medicine targets and the evaluation of new medicines, which enables development of new drugs from a high-throughput to high-content base.
Indd 23 5/2/2012 9:22:33 AM 24 INTRODUCTION OF SYSTEMS BIOLOGY IN TRADITIONAL CHINESE MEDICINE (TCM) syndrome models before and after interference by the material media and component group compatibility were investigated; and compatibility theories for the Jun (Renshen), Chen (Baizhu), Zuo (Fuling), and Shi (Gancao) herbs in the Sijunzi decoction were validated from the constructional relationship of effective substances and pharmacological correlation of integrated systems biology parameters. The essence of the TCM pharmacodynamic evaluation is how to establish the correlation between the syndrome and the drug’s therapeutic effect.
2 Method to study the relationship between effective chemome and efﬁcacy of TCM formula. A: compounds of component group; B: indicators of model; C: compounds of effective component group. components are ejected from the global chemome. Chemomics provides a new “omics” approach to develop modernized composite medicine, where the phytochemical composition of a herbal formula with demonstrated clinical efﬁcacy is regarded as a global chemome, which can be simpliﬁed successively through bioactivity-guided screening to achieve an optimized chemome with minimal phytochemical composition for further drug development, while maintaining its curative effect for a speciﬁc disease.