Surfactants and Polymers in Drug Delivery by Martin Malmsten

By Martin Malmsten

The ebook covers the fundamentals of surfactant and polymer floor task and self-assembly, a few of the kinds of constructions shaped through such compounds, and the way they're utilized in drug supply. It additionally discusses solubilization of gear in micellar platforms, liquid crystalline levels shaped by means of PEO-PPO-PEO block copolymers and different copolymers and surfactants, caused drug-release from liposome formulations, microemulsions shaped via ionic and nonionic surfactants, and masses extra.

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By Martin Malmsten

The ebook covers the fundamentals of surfactant and polymer floor task and self-assembly, a few of the kinds of constructions shaped through such compounds, and the way they're utilized in drug supply. It additionally discusses solubilization of gear in micellar platforms, liquid crystalline levels shaped by means of PEO-PPO-PEO block copolymers and different copolymers and surfactants, caused drug-release from liposome formulations, microemulsions shaped via ionic and nonionic surfactants, and masses extra.

Show description

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For example, for a lamellar phase, the surfactant molecules occupy a cylindrical space and v ϭ a ⋅ l, that is, cpp ϭ 1. , the larger the headgroup area in relation to the surfactant volume. For reversed structures, the cpp increases in the order lamellar → reversed hexagonal → reversed micellar. It follows that the packing of the surfactant molecules, and hence also the type of surfactant aggregate formed, depends on the values of a, v, and l, and that changing any of these parameters influences the structure of surfactant aggregates formed.

In the case of micellizing surfactants, self-diffusion measurements contain information on both free molecules and molecules in the micellar state. , D obs ϭ p mic D mic ϩ p free D free (1) where D i and p i are the diffusion coefficient and the fraction in state i. Since the diffusion coefficients of the free surfactant molecules can be determined from measurements below the cmc, since the diffusion coefficient of the micelles may be obtained through measurement of the diffusion coefficient of a hydrophobic molecule solubilized in the micellar core, and since the total concentration is known, the concentration of micelles and free surfactant micelles can be extracted.

Since micellization is promoted by an increasing PPO content and precluded by branching of the copolymer, the solubilization is improved with an increased PPO content, and is poorer for tetrabranched than for linear block copolymers. As long as spherical micelles are formed, higher molecular weight block copolymers form larger micelles than low molecular weight ones, and are therefore expected to be more efficient solubilizers. However, spherical micelles are not always formed, and both the aggregation number and the shape of the micelles may change on solubilization, which affect the latter.

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