SOME ASPECTS O F THE CHEMISTRY AND TOXICACTION OF ORGANIC by Saunders, Todd

By Saunders, Todd

Through the first global struggle in depth study on poisonous chemicals was once performed in the entire belligerent nations. a lot of this study had, and nonetheless has, a slightly restrictedinterest, however the experiences on natural compounds containing phosphorus and fluorine, initiated during this nation by way of Dr Saunders and his colleagues, have had vast epercussions. not just have they prompted stories in enzymology or even scientific medication, yet they've got completed commercial value within the common box of pest keep watch over. the improvement of recent systemic pesticides, which stems from the autonomous wartime reviews of Dr Saunders in England and Dr Schrader in Germany, is certainly a desirable tale and one that is much less famous than it's going to be. The veil of secrecy overlaying the early paintings and the quite piecemeal uncovering of it within the years following the warfare have brought on many chemists and biologists to stay very ill-informed in regards to the improvement of data within the box of natural phosphorus and fluorine compounds. the current monograph should still do a lot to treatment this scenario. even though meant basically for chemists, the ebook comprises a lot info at the pharmacology of the compounds mentioned; this can be fairly worthwhile considering a formal appreciation of the organic heritage is key to the chemist who needs to work out the paintings in right viewpoint. As one that has had the privilege of following the paintings of Dr Saunders and his colleagues heavily from its beginnings in 1939, i'm fairly happy that he has now written this authoritative account of it and that i commend the monograph to chemists and biologists as a mine of knowledge on essentially the most fascinating chemical advancements which originated in paintings began lower than the tension of battle.

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By Saunders, Todd

Through the first global struggle in depth study on poisonous chemicals was once performed in the entire belligerent nations. a lot of this study had, and nonetheless has, a slightly restrictedinterest, however the experiences on natural compounds containing phosphorus and fluorine, initiated during this nation by way of Dr Saunders and his colleagues, have had vast epercussions. not just have they prompted stories in enzymology or even scientific medication, yet they've got completed commercial value within the common box of pest keep watch over. the improvement of recent systemic pesticides, which stems from the autonomous wartime reviews of Dr Saunders in England and Dr Schrader in Germany, is certainly a desirable tale and one that is much less famous than it's going to be. The veil of secrecy overlaying the early paintings and the quite piecemeal uncovering of it within the years following the warfare have brought on many chemists and biologists to stay very ill-informed in regards to the improvement of data within the box of natural phosphorus and fluorine compounds. the current monograph should still do a lot to treatment this scenario. even though meant basically for chemists, the ebook comprises a lot info at the pharmacology of the compounds mentioned; this can be fairly worthwhile considering a formal appreciation of the organic heritage is key to the chemist who needs to work out the paintings in right viewpoint. As one that has had the privilege of following the paintings of Dr Saunders and his colleagues heavily from its beginnings in 1939, i'm fairly happy that he has now written this authoritative account of it and that i commend the monograph to chemists and biologists as a mine of knowledge on essentially the most fascinating chemical advancements which originated in paintings began lower than the tension of battle.

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602,446 (Ministry of Supply, McCombie, Saunders, Chapman and Heap, 17 April 1944). 1 J. Amer. Chem. Soc. 1939, 61, 2937. 50 ESTERS OF PHOSPHOROFLUOBIDIC ACID wise fluorination of phosphorus oxytrichloride by antimony trifluoride (and pentachloride as catalyst) is shown in fig. 10. On a kilogram scale the yield of pure phosphorus oxydichlorofluoride was ca. 20 per cent. Among many esters, di-w-propyl and di-isopropyl phosphorofluoridate were prepared by the action of phosphorus oxydichlorofluoride on n-propyl and isopropyl alcohol respectively.

Without a solvent the yield was 86-4 per cent. Chlorination of the hydrogen phosphite gave 76 per cent of pure di-isopropyl phosphorochloridate (stage I I ) . ) By heating the phosphorochloridate, dissolved in a solvent such as dry benzene, with an inorganic fluoride such as dry sodium fluoride (stage I I I ) , pure di-isopropyl phosphorofluoridate was obtained in 90 per cent yield. Thus the phosphorofluoridate was obtainable in a pure condition by a three-stage process from phosphorus trichloride and isopropyl alcohol, and the overall yield was ca.

1 Report no. 9 to Ministry of Supply by McCombie and Saunders, 10 April 1943.

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