Phospholipid Metabolism in Apoptosis (Subcellular by Peter J. Quinn (Editor), Valerian E. Kagan (Editor)

By Peter J. Quinn (Editor), Valerian E. Kagan (Editor)

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By Peter J. Quinn (Editor), Valerian E. Kagan (Editor)

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Extra resources for Phospholipid Metabolism in Apoptosis (Subcellular Biochemistry, Volume 36) (Subcellular Biochemistry)

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1999, An exegesis of IAPs: salvation and surprises from BIR motifs. Trends Cell Biol. 9: 323-328. , 1997, forms an ion channel in synthetic lipid membranes, Nature 385: 353-357. , 2001, A reversible component of mitochondrial respiratory dysfunction in apoptosis can be rescued by exogenous cytochrome c, EMBO J. 20: 661671. , 1996, X-ray and NMR structure of human an inhibitor of programmed cell death, Nature 381: 335-341. , 1997, Protein import into mitochondria, Annu. Rev. Biochem. 66: 863-917.

Therefore, the interaction of PHGPx with the mitochondrial phospholipid cardiolipin may be important in the physiological function of the antioxidant enzyme. In this section, we show that cardiolipin hydroperoxide is a potent substrate of PHGPx and that cardiolipin itself potentially activates PHGPx. On the basis of these findings, we discuss the physiological role of PHGPx in protecting mitochondrial function from oxidative disruption. 1, we examined the activity of PHGPx toward this lipid hydroperoxide as a substrate.

1985, ADP/ATP carrier protein from beef heart mitochondria has high amounts of tightly bound cardiolipin, as revealed by nuclear magnetic resonance. , 1996, Specific cardiolipin binding interferes with labeling of sulfhydryl residues in the adenosine diphosphate/adenosine triphosphate carrier protein from beef heart mitochondria. , 1998, Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization.

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