New Carbon–Carbon Coupling Reactions Based on by Rui Shang

By Rui Shang

This thesis provides the newest advancements in new catalytic C–C bond formation tools utilizing simply obtainable carboxylate salts via catalytic decarboxylation with sturdy atom financial system, and applying the sustainable point iron because the catalyst to without delay turn on C–H bonds with excessive step potency. during this regard, it explores a mechanistic realizing of the newly chanced on decarboxylative couplings and the catalytic reactivity of the iron catalyst with assistance from density practical thought calculation.

The thesis is split into components, the 1st of which makes a speciality of the improvement of a chain of formerly unexplored, reasonably cheap carboxylate salts as necessary development blocks for the formation of varied C–C bonds to entry invaluable chemical substances. In flip, the second one half is dedicated to numerous new C–C bond formation methodologies utilizing the main ubiquitous transition steel, iron, as a catalyst, and utilizing the ever present C–H bond because the coupling partner.

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By Rui Shang

This thesis provides the newest advancements in new catalytic C–C bond formation tools utilizing simply obtainable carboxylate salts via catalytic decarboxylation with sturdy atom financial system, and applying the sustainable point iron because the catalyst to without delay turn on C–H bonds with excessive step potency. during this regard, it explores a mechanistic realizing of the newly chanced on decarboxylative couplings and the catalytic reactivity of the iron catalyst with assistance from density practical thought calculation.

The thesis is split into components, the 1st of which makes a speciality of the improvement of a chain of formerly unexplored, reasonably cheap carboxylate salts as necessary development blocks for the formation of varied C–C bonds to entry invaluable chemical substances. In flip, the second one half is dedicated to numerous new C–C bond formation methodologies utilizing the main ubiquitous transition steel, iron, as a catalyst, and utilizing the ever present C–H bond because the coupling partner.

Show description

Read Online or Download New Carbon–Carbon Coupling Reactions Based on Decarboxylation and Iron-Catalyzed C–H Activation PDF

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24 Decarboxylative cross-coupling involving a 3,4-dioxypyrrole reported by Reynolds et al. 25 Pioneering studies of Cu-mediated decarboxylative biaryl couplings by Nilsson et al. 4. Cu-only systems In the 1960s Nilsson et al. 25). This early example is stoichiometric in the presence of copper catalyst, whereas the first catalytic example for the use of Cu in decarboxylative cross-coupling was reported by Shang and Liu et al. in 2009. This is an efficient way to prepare the asymmetric polyfluorinated biaryls from polyfluorinated benzoic acids and aryl halides (aryl bromides and iodides) [33].

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