By Stephen P. Coburn
Built from a chain of meetings to facilitate the appliance of mathematical modeling to experimental food, this e-book comprises examples of purposes of modeling to supplementations, proteins, amino acids, and effort metabolism. It contains mathematical therapy of complicated metabolic tactics. content material: entrance conceal; Advances in foodstuff and foodstuff study, quantity forty; Copyright web page; Contents; individuals to quantity forty; Preface; Editor's word; half I: nutrition METABOLISM; bankruptcy 1. Quantitative and Conceptual Contributions of Mathematical Modeling to present perspectives on nutrition A Metabolism, Biochemistry, and nutrients; bankruptcy 2. Mathematical Modeling in nutrients: developing a Physiologic Compartmental version of the Dynamics of ß-Carotene Met; bankruptcy three. Experimental ways to the examine of ß-Carotene Metabolism: strength of a 13C Tracer method of Modeling ß-Caro. bankruptcy four. Modeling of Folate MetabolismChapter five. Molecular Biology in foodstuff examine: Modeling of Folate Metabolism; bankruptcy 6. Modeling diet B6 Metabolism; half II: PROTEIN AND AMINO ACID METABOLISM; bankruptcy 7. Interrelationships among Metabolism of Glycogen Phosphorylase and Pyridoxal Phosphate--Implications in McArdle's sickness; bankruptcy eight. Metabolism of standard and Met30 Transthyretin; bankruptcy nine. Use of a 4 Parameter L. summary: constructed from a sequence of meetings to facilitate the applying of mathematical modeling to experimental meals, this booklet comprises examples of purposes of modeling to supplementations, proteins, amino acids, and effort metabolism. It comprises mathematical remedy of complicated metabolic approaches
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Extra resources for Mathematical Modeling in Experimental Nutrition: Vitamins, Proteins, Methods
The reason for building a physiologic compartmental model is to realize as complete a description as possible of a metabolic system under investigation. The model is built to develop an analogy of the system under investigation and to obtain values for critical parameters of the model so that unobserved portions of the dynamic and kinetic behavior of the system under investigation can be predicted. Specific information obtained about the system under investigation includes the number of pools and their sizes, how they are connected, and how their masses change over time.
The Process of Constructing a Compartmental Model IV. Intermediate Models V. Statistical Considerations VI . The Final Model VII. System Behavior Proposed by the Model VIII. Unobservable System Behavior Proposed by the Model IX. Empirical Description of the Experimental Observations X. Final Encouraging Words References 11. ' Corresplonding author. 25 Copyright 0 1996 by Academic Press, Inc. All rights of reproduction in any form reserved. 26 PART I VITAMIN METABOLISM 1. , increased intakes of some foods and/or nutrients such as fruits and vegetables and antioxidant vitamins and reduced intakes of others such as calories and saturated fats, an investigation of variations in health status produced by these practices is required.
B. (1990b). Experimental and kinetic methods for studying vitamin A dynamics in vivo. I n “Methods in Enzymology” (L. ), Vol. 190, pp. 304-317. Academic Press, San Diego, CA. Green, M. , and Green, J. B. (1994). Vitamin A intake and status influence retinol balance, utilization and dynamics in the rat. 1. Nutr. l24,2477-2485. Green, M. , and Green, J. B. (1985). A multicompartmental model of vitamin A kinetics in rats with marginal liver vitamin A stores. J. Lipid Res. 26,806-818. Green, M. , Green, 1.