Marihuana and Medicine by Hélène Peters, Gabriel G. Nahas (auth.), Gabriel G. Nahas

By Hélène Peters, Gabriel G. Nahas (auth.), Gabriel G. Nahas MD, PhD, DSc, Kenneth M. Sutin MD, MS, David Harvey PhD, Stig Agurell PhD, PharmD, DSc, Nicholas Pace MD, Robert Cancro MD (eds.)

In Marihuana and medication, top physicians and scientists from around the globe significantly assessment the pharmacological and molecular foundation of the healing homes of marihuana and its energetic element, THC. They aspect the extensive array of marihuana's results on mind functionality, the immune approach, female and male reproductive functionality, and cardiac and pulmonary functionality, in addition to review its medical purposes in psychiatry, glaucoma, soreness administration, melanoma chemotherapy, and AIDS remedy. Their paintings exhibits that marihuana impairs mind and reproductive functionality, is damaging to the immune method, is extra destructive while smoked to the lung than tobacco smoke, and isn't an efficient, medically applicable healing motor vehicle for THC. The editors have additionally integrated key historic fabric tracing the debatable background of marihuana in technological know-how and medication over the centuries.
Marihuana and Medicine's file of the most recent findings at the pharmacological, pharmacodynamic, and molecular mechanisms of marihuana may be crucial analyzing for clinicians, psychiatrists, pharmacologists, coverage makers, health-care staff, and lawyers.






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By Hélène Peters, Gabriel G. Nahas (auth.), Gabriel G. Nahas MD, PhD, DSc, Kenneth M. Sutin MD, MS, David Harvey PhD, Stig Agurell PhD, PharmD, DSc, Nicholas Pace MD, Robert Cancro MD (eds.)

In Marihuana and medication, top physicians and scientists from around the globe significantly assessment the pharmacological and molecular foundation of the healing homes of marihuana and its energetic element, THC. They aspect the extensive array of marihuana's results on mind functionality, the immune approach, female and male reproductive functionality, and cardiac and pulmonary functionality, in addition to review its medical purposes in psychiatry, glaucoma, soreness administration, melanoma chemotherapy, and AIDS remedy. Their paintings exhibits that marihuana impairs mind and reproductive functionality, is damaging to the immune method, is extra destructive while smoked to the lung than tobacco smoke, and isn't an efficient, medically applicable healing motor vehicle for THC. The editors have additionally integrated key historic fabric tracing the debatable background of marihuana in technological know-how and medication over the centuries.
Marihuana and Medicine's file of the most recent findings at the pharmacological, pharmacodynamic, and molecular mechanisms of marihuana may be crucial analyzing for clinicians, psychiatrists, pharmacologists, coverage makers, health-care staff, and lawyers.






Show description

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C. Effects of Marihuana Inhalation on Spermatogenesis of the Rat. pp. 359-366. , and Huang H. Changes in Human Spermatazoa Associated with HIgh-Dose Marihuana Smoking. pp. 367-378. Rosenkrantz, H. Effects of Cannabis on Fetal Development of Rodents. pp. 411-430. , and Bartke A Maternal or Paternal Exposure to Cannabinoids Affects Central Neurotransmitter Levels and Reproductive Function in Male Offspring. pp. 441-447. P. Reproduction in Rhesus Monkeys Chronically Exposed to Delta-9-Tetrahydrocannabinol.

I'l1_ THC depresses rewarding self-stimulation behavior, and tolerance develops to this. But we cannot yet reliably link these results to definite neurochemical changes. The curious relation of i'l1_ THC to opiates remains: totally different chemical structures; a number of shared effects; a number of interactions with naloxone; and curious patterns of crosstolerance, never fully reciprocal, and varying with the test used. The suggestions that THC may change the affinity of opiates or of related endogenous peptides for their receptors, or that they release such peptides, deserve detailed study.

About 10% of the biliary metabolites are enterohepatically recirculated. Only a small percentage of the metabolites appear to be retained by the tissues, for example, in the dog although 16-29% ofthe administered dose is retained in the tissues after 100 hours, only 11-20% of this has been attributed to metabolites. -C. Jardillier The effects of different cannabinoids (psychoactive and nonpsychoactive) on several mammalian cells lines are exerted at micromolar concentrations. ACTION AT THE LEVEL OF THE PLASMA MEMBRANE These effects are numerous and related in most cases to the lipophilic nature of THC and of its derivatives.

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