By Arthur E. Martell (Eds.)
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Extra info for Inorganic Chemistry in Biology and Medicine
These studies have analyzed the i n d u s t r i a l worker's exposure to these metals, or have examined s e l e c t e d populations having excessive exposure to these metals i n t h e i r d r i n k i n g water, the atmosphere adjacent to t h e i r h a b i t a t i o n , etc. ). It should, however, be pointed out that n i c k e l and i t s compound c l a s s of metal carcinogens i n humans. There are several other metals, i n c l u d i n g b e r y l l i u m , which have also been l i n k e d to human cancer, but the most important metal carcinogens have been l i s t e d above (11).
N i c k e l and i r o n d i d not i n t e r a c t to a f f e c t hematocrit and hemoglobin when i r o n was s u p p l i e d as f e r r i c - f e r r o u s s u l f a t e . The form of d i e t a r y i r o n a l s o i n f l u e n c e d the e f f e c t of n i c k e l on hematocrit and hemoglobin. When f e r r i c s u l f a t e was fed (Experiments 1 and 3 ) , both parameters were s i g n i f i c a n t l y lower i n n i c k e l - d e p r i v e d than -supplemented r a t s . In Experiment 2 the e f f e c t of n i c k e l was much l e s s marked than i n Experiments 1 and 3.
In Experiment 2, the greatest d i f f e r e n c e was i n r a t s f e d no supplemental i r o n There were some d i f f e r e n c e e s p e c i a l l y when the d i e Experiment 3, hematocrit and hemoglobin l e v e l s were s i g n i f i c a n t l y depressed i n a l l groups fed 25 yg i r o n / g of d i e t , although the depression was l e s s severe i n nickel-supplemented than -deprived r a t s . In Experiment 1, with 25 yg of i r o n / g of d i e t , hematocrit and hemoglobin were depressed only i n n i c k e l deprived r a t s ; values were near normal i n r a t s f e d 5 or 50 yg of n i c k e l / g of d i e t .