By C. Hoffmann, J. Rockstroh, B. Kamps
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Extra resources for HIV Medicine 2006
In addition to the decline in CD4+ T-cell counts, qualitative impairments of CD4+ T-cell function are perhaps the most characteristic abnormalities detected in HIV-1 infection. The impairment of HIV-1-specific CD4+ Tcell function occurs very early in acute infection (Rosenberg 1997, Altfeld 2001, Lichterfeld 2004), potentially due to the preferential infection of virus-specific CD4+ T-cells by the virus (Douek 2002). This is followed by a functional impairment of CD4+ T-cell responses to other recall antigens, as well as a reduced responsiveness to novel antigens (Lange 2003).
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Id=10075982 12. Kahn JO, Walker BD. Acute human immunodeficiency virus type 1 infection. New England Journal of Medicine 1998,339:33-39. 13. Kaslow RA, Carrington M, Apple R, Park L, Munoz A, Saah AJ, et al. Influence of combinations of human major histocompatibility complex genes on the course of HIV-1 infection. Nat Med 1996,2:405-411. id=8597949 14. Kaufmann DE, Lichterfeld M, Altfeld M, Addo MM, Johnston MN et al. Limited Durability of Viral Control following Treated Acute HIV Infection. PLOS Medicine, November 2004.