By Professor Dr. János Fehér, Professor Dr. Géza Csomós, Dr. András Vereckei (auth.)
This publication goals to supply a concise evaluation of the scientific points of loose radical reactions. previously, there were broad reports of the topic in a physiological, pathophysiological and biochemical context. right here, in spite of the fact that, the authors be aware of the biology of loose radical reactions as proper to scientific perform, emphasizing that the subject is not only a department of uncomplicated technology. as a result, a quick creation on chemical and organic facets is through an in depth dialogue of the position performed via unfastened radical reactions within the pathogenesis and improvement of numerous human illnesses and in healing probabilities. The precis of information from the literature is supplemented by way of the authors' personal experimental effects. The presentation can help clinical researchers to note up to now unknown connections between a number of illnesses and to lead them to conscious of the existance of the so-called "free radical diseases".
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Extra resources for Free Radical Reactions in Medicine
If the free radicals are produced at a slow rate, or if their half-life is short owing to their high reactivity, they cannot be detected by ESR spectroscopy. In such cases the spin trapping method is used, which is, in fact, indirect ESR spectroscopy. In spin trapping the spectrum of a known stable compound is changed by the trapping of an unstable radical. The structure of the radical trapped is deduced from the ESR spectrum of the resultant relatively stable product [142, 280, 281, 344, 346].
13) that O2, is released by the interaction of cytochrome P-450 with pseudosubstrates. According to the hypothesis of Hornsby and Crivello, the same occurs for the interaction of cytochromes participating in the synthesis of adrenocortical hormones with some steroids. The ROls produced may damage cytochrome P-450 directly, or by inducing LPO. P-450 can use the lipid peroxides formed ROOH as oxygen donor substrates, while the a1koxy radical RO' is formed by the c1eavage of the 0-0 bond. The reactivity of the alkoxy radical is almost as high as that of 'OH, and that is how cytochrome P-450 is deactivated.
13. Free radical formation in the endoplasmic reticulum. 14. Postulated mechanism of free radical formation in the cytochrome P-450 system. Ferricytochrome P-450 binds substrates or pseudosubstrates (SH) and a P-450-substrate (pseudosubstrate)- O2 complex ist formed. If substrate is bound, the cycle is terminated by the formation of hydoxylated product (SOH) and water. In case of pseudosubstrate participation, however, the complex is decomposed and ferricytochrome P-450, 0;-· and the pseudosubstrate are released.