Drug transporters. Volume 2, Recent advances and emerging by Glynis Nicholls, Kuresh Youdim, David Thurston, David Fox,

By Glynis Nicholls, Kuresh Youdim, David Thurston, David Fox, Bruno Stieger, Hideyuki Saito, David Dickens, Lena Gustavsson, Pradeep Sharma, Nico Scheer, Varma Manthena, Silke Simon, Susan Cole, Nick Plant, Ichiro Leiri, David Marcus, Bente Steffansen, Karel

Understanding and quantifying the results of membrane transporters in the human physique is key for modulating drug protection and drug efficacy. the 1st quantity comprehensively reviewed present wisdom and methods within the transporter sciences and their kin to drug metabolism and pharmacokinetics. during this moment quantity on Drug Transporters, emphasis is put on rising sciences and applied sciences, highlighting power components for destiny advances in the drug transporter field.


The issues lined in either volumes make sure that all appropriate facets of transporters are defined around the drug improvement strategy, from in silico versions and preclinical instruments via to the capability effect of transporters within the health center. Contributions are integrated from specialist leaders within the box, at-the-bench business scientists, well known lecturers and foreign regulators. Case reports and rising advancements are highlighted, including the benefits and barriers of the on hand equipment and instruments, and vast references to experiences on particular in-depth subject matters also are incorporated for these wishing to pursue their wisdom extra.


As such, this article serves as a vital guide of knowledge for postgraduate scholars, lecturers, business scientists and regulators who desire to comprehend the function of transporters in absorption, distribution, metabolism, and excretion methods. additionally, it's also an invaluable reference software at the versions and calculations essential to expect their impact on human pharmacokinetics and pharmacodynamics.

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By Glynis Nicholls, Kuresh Youdim, David Thurston, David Fox, Bruno Stieger, Hideyuki Saito, David Dickens, Lena Gustavsson, Pradeep Sharma, Nico Scheer, Varma Manthena, Silke Simon, Susan Cole, Nick Plant, Ichiro Leiri, David Marcus, Bente Steffansen, Karel

Understanding and quantifying the results of membrane transporters in the human physique is key for modulating drug protection and drug efficacy. the 1st quantity comprehensively reviewed present wisdom and methods within the transporter sciences and their kin to drug metabolism and pharmacokinetics. during this moment quantity on Drug Transporters, emphasis is put on rising sciences and applied sciences, highlighting power components for destiny advances in the drug transporter field.


The issues lined in either volumes make sure that all appropriate facets of transporters are defined around the drug improvement strategy, from in silico versions and preclinical instruments via to the capability effect of transporters within the health center. Contributions are integrated from specialist leaders within the box, at-the-bench business scientists, well known lecturers and foreign regulators. Case reports and rising advancements are highlighted, including the benefits and barriers of the on hand equipment and instruments, and vast references to experiences on particular in-depth subject matters also are incorporated for these wishing to pursue their wisdom extra.


As such, this article serves as a vital guide of knowledge for postgraduate scholars, lecturers, business scientists and regulators who desire to comprehend the function of transporters in absorption, distribution, metabolism, and excretion methods. additionally, it's also an invaluable reference software at the versions and calculations essential to expect their impact on human pharmacokinetics and pharmacodynamics.

Show description

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Extra resources for Drug transporters. Volume 2, Recent advances and emerging technologies

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Nakanishi and I. Tamai, Local Drug-Drug Interaction of Donepezil with Cilostazol at Breast Cancer Resistance Protein (ABCG2) Increases Drug Accumulation in Heart, Drug Metab. , 2016, 44(1), 68–74. N. Jung, C. Lehmann, A. Rubbert, M. Knispel, P. Hartmann, J. van Lunzen, H. J. Stellbrink, G. Faetkenheuer and D. Taubert, Relevance of the organic cation transporters 1 and 2 for antiretroviral drug therapy in human immunodeficiency virus infection, Drug Metab. , 2008, 36(8), 1616–1623. T. F. Solbach, M.

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Prasad, P. Seth, D. P. Rajan, F. H. Leibach, J. Chen, S. J. Conway and V. Ganapathy, Functional characteristics and tissue distribution pattern of organic cation transporter 2 (OCTN2), an organic cation/carnitine transporter, J. Pharmacol. Exp. , 1999, 290(3), 1482–1492. I. Tamai, Pharmacological and pathophysiological roles of carnitine/ organic cation transporters (OCTNs: SLC22A4, SLC22A5 and Slc22a21), Biopharm. , 2013, 34(1), 29–44. ¨ck, S. Oswald, K. Draber, K. Meissner, L. Eckel, M. Bo ¨hm, M.

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