By Lazaros C. Triarhou (auth.)
This ebook is the end result of fifteen years of study at the transplantation of dopaminergic neurons within the striatum of the weaver mouse (wv/wv), a neurological mutant characterised by way of genetically-determined degeneration of midbrain dopamine neurons. This mutant constitutes the single to be had laboratory version with a protracted ailment that mimics Parkinson's sickness. Structural and useful points of intrastriatal mesencephalic neuron grafting into the weaver version are reviewed, together with histochemical correlates of graft survival and integration, numerical features of donor mobilephone survival, ultrastructural findings on synaptogenesis, neurochemical indices of dopamine uptake and receptor binding, gene expression of structural and neurotransmitter-receptor comparable molecules, degrees of striatal amino acid receptors, and behavioural results of unilateral and bilateral neuronal transplantations.
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Additional info for Dopaminergic Neuron Transplantation in the Weaver Mouse Model of Parkinson’s Disease
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106 Further, wvlwv granule cells were found to create a dysmorphic appearance in +1+ Golgi epithelial cells; such an effect could be due to an impaired trophic interaction between weaver granule cells and normal astrocytes, possibly mediated by astrotactin, a 100 kDa protein localized to cerebellar granule cells and reduced by more than 95% in the weaver cerebellum. I08-110 The grafts displayed a layered cellular organization reminiscent of the normal cerebellar cortex, with identifiable molecular, Purkinje cell and granule cell layers.
I04 Neurite outgrowth was followed in cerebellar cultures by measuring the mean total length of processes generated per neuron; after six days in vitro, that parameter is reduced by 88% in wv/wv and by 53% in wv/+, compared to +/+ cerebellum. Time-lapse microcinematography shows that the defect in homozygous weaver cells is not in the initiation ofneurites, but in neurite maintenance and elongation. 106 Further, wvlwv granule cells were found to create a dysmorphic appearance in +1+ Golgi epithelial cells; such an effect could be due to an impaired trophic interaction between weaver granule cells and normal astrocytes, possibly mediated by astrotactin, a 100 kDa protein localized to cerebellar granule cells and reduced by more than 95% in the weaver cerebellum.