Cytokines, Stress, and Depression by Michael Irwin (auth.), Robert Dantzer, Emmanuelle E.

By Michael Irwin (auth.), Robert Dantzer, Emmanuelle E. Wollman, Raz Yirmiya (eds.)

Cytokines have been characterised within the early eighties as communique mole­ cules among immune cells, and among immunocytes and different peripheral cells, reminiscent of fibroblasts and endothelial cells. They play a key function within the law of the immune reaction and the coordination of the host reaction to an infection. according to those organic homes, not anyone may have estimated that one decade later cytokines might burst upon neurosciences and permeate into numerous avenues of present study. In neurology, the relationship among cytokines and irritation, and the demonstration of a pivotal function of a few of those molecules in mobile dying by means of apoptosis, triggered the research in their involvement in different neurological illnesses related to an inflammatory part, together with a number of sclerosis, mind trauma, stroke, and Alzheimer's ailment. This circulate begun within the past due eighties, and the corresponding box of analysis, referred to as neuroimmunology, is shortly booming. In psychiatry, even if, the connection among cytokines and psychological problems used to be less glaring and took longer to materialize. the 1st indication that cytokines can be enthusiastic about psychopathology got here from cancerology and inner medicine.

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By Michael Irwin (auth.), Robert Dantzer, Emmanuelle E. Wollman, Raz Yirmiya (eds.)

Cytokines have been characterised within the early eighties as communique mole­ cules among immune cells, and among immunocytes and different peripheral cells, reminiscent of fibroblasts and endothelial cells. They play a key function within the law of the immune reaction and the coordination of the host reaction to an infection. according to those organic homes, not anyone may have estimated that one decade later cytokines might burst upon neurosciences and permeate into numerous avenues of present study. In neurology, the relationship among cytokines and irritation, and the demonstration of a pivotal function of a few of those molecules in mobile dying by means of apoptosis, triggered the research in their involvement in different neurological illnesses related to an inflammatory part, together with a number of sclerosis, mind trauma, stroke, and Alzheimer's ailment. This circulate begun within the past due eighties, and the corresponding box of analysis, referred to as neuroimmunology, is shortly booming. In psychiatry, even if, the connection among cytokines and psychological problems used to be less glaring and took longer to materialize. the 1st indication that cytokines can be enthusiastic about psychopathology got here from cancerology and inner medicine.

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Schaefer, S. (1991). Natural killer cell activity in adolescents with major depression. Biological Psychiatry, 29, 481-484. Sheridan, J. , & Zwilling, B. (1994). Psychoneuroimmunology: stress effects on pathogenesis and immunity during infection. Clinical Microbiological Reviews 7, 200-212. Steiger, A. & Holsboer, F. (1997). Nocturnal secretion of prolactin and Cortisol and the sleep EEG in patients with major endogenous depression during an acuted episode and after full remission. Psychiatry Research, 72, 81-88.

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