Comprehensive Medicinal Chemistry II, Eight-Volume Set, by David J Triggle, John B Taylor (editors)

By David J Triggle, John B Taylor (editors)

The 1st variation of finished Medicinal Chemistry was once released in 1990 and was once rather well acquired. finished Medicinal Chemistry II is way greater than an easy updating of the contents of the 1st version. thoroughly revised and improved, this new version has been refocused to mirror the numerous advancements and adjustments during the last decade in genomics, proteomics, bioinformatics, combinatorial chemistry, high-throughput screening and pharmacology, and extra. The content material contains the main updated, authoritative and complete reference textual content on modern medicinal chemistry and drug study, protecting significant healing periods and ambitions, examine process and enterprise, high-throughput applied sciences, computer-assisted layout, ADME and chosen case histories. it's this insurance of the method, applied sciences, rules and purposes of medicinal chemistry in one paintings that would make finished Medicinal Chemistry II a special paintings of reference and a unmarried element of access to the literature for pharmaceutical and biotechnology scientists of all disciplines and for plenty of executives as well.Also to be had on-line through ScienceDirect (2006) - that includes vast searching, looking out, and inner cross-referencing among articles within the paintings, plus dynamic linking to magazine articles and summary databases, making navigation versatile and straightforward. for additional info, pricing suggestions and availability stopover at www.info.sciencedirect.com. * Comprehensively experiences - the suggestions, applied sciences, ideas and functions of contemporary medicinal chemistry * offers an international and present standpoint of modern drug discovery method and discusses the main healing periods and goals* incorporates a particular choice of case stories and private assays reviewing the invention and improvement of key medicines

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By David J Triggle, John B Taylor (editors)

The 1st variation of finished Medicinal Chemistry was once released in 1990 and was once rather well acquired. finished Medicinal Chemistry II is way greater than an easy updating of the contents of the 1st version. thoroughly revised and improved, this new version has been refocused to mirror the numerous advancements and adjustments during the last decade in genomics, proteomics, bioinformatics, combinatorial chemistry, high-throughput screening and pharmacology, and extra. The content material contains the main updated, authoritative and complete reference textual content on modern medicinal chemistry and drug study, protecting significant healing periods and ambitions, examine process and enterprise, high-throughput applied sciences, computer-assisted layout, ADME and chosen case histories. it's this insurance of the method, applied sciences, rules and purposes of medicinal chemistry in one paintings that would make finished Medicinal Chemistry II a special paintings of reference and a unmarried element of access to the literature for pharmaceutical and biotechnology scientists of all disciplines and for plenty of executives as well.Also to be had on-line through ScienceDirect (2006) - that includes vast searching, looking out, and inner cross-referencing among articles within the paintings, plus dynamic linking to magazine articles and summary databases, making navigation versatile and straightforward. for additional info, pricing suggestions and availability stopover at www.info.sciencedirect.com. * Comprehensively experiences - the suggestions, applied sciences, ideas and functions of contemporary medicinal chemistry * offers an international and present standpoint of modern drug discovery method and discusses the main healing periods and goals* incorporates a particular choice of case stories and private assays reviewing the invention and improvement of key medicines

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Additional info for Comprehensive Medicinal Chemistry II, Eight-Volume Set, Volume 6 : Therapeutic Areas I: Central Nervous System, Pain, Metabolic Syndrome, Urology, Gastrointestinal and Cardiovascular

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In fact, nicotine appears to produce a modest transient improvement in cognitive and sensory deficits in these patients. 39 However, these views must be interpreted with caution. Overall, schizophrenic patients have a high degree of comorbid abuse of a variety of substances including nicotine, alcohol, cannabis, cocaine, and amphetamine. Importantly, the rate of substance abuse is higher than in the general population for all of these substances in spite of the fact that such abuse is associated with poorer outcomes, exacerbation of positive symptoms, increased hospitalization, and increased frequency of homelessness.

Kendler, K. S. Am. J. Psychiatry 2003, 160, 1549–1553. 25. ; Faraone, S. ; Tsuang, M. T. Psychiatr. Res. 2005, 133, 111–122. 26. Owen, M. ; O’Donovan, M. C. Trends Genet. 2005, 21, 518–525. 27. Williams, M. Curr. Opin. Investig. Drugs 2003, 4, 31–36. 28. Tunbridge, E. ; Harrison, P. ; Weinberger, D. R. Biol. Psychiatry 2006, 60, 141–151. 29. ; Malhotra, A. ; Finn, C. ; Plocik, A. ; Lake, S. ; Kane, J. ; Kucherlapati, R. Behav. Brain Funct. 2005, 1, 19. 30. Harrison, P. ; Law, A. J. Biol. Psychiatry 2006, 60, 132–140.

Conley, R. ; Buchanan, R. W. In Pharmacological Management of Neurological and Psychiatric Disorders; Enna, S. , Coyle, J. ; McGraw-Hill: New York, 1998, pp 27–51. 3. Deniker, P. In Discoveries in Pharmacology: Vol. 1, Psycho- and Neuro-Pharmacology; Parnham, M. ; Elsevier: Amsterdam, the Netherlands, 1983, pp 163–180. 4. First, M. ; Tasman, A. In DSM-IV-TR Mental Disorders: Diagnosis, Etiology and Treatment; John Wiley: Chichester, UK, 2004, pp 639–701. 5. McGurk, S. R. J. Psychiatr. Pract. 2000, 6, 190–196.

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