By Tibor Tot
Large-section histopathology widens your perspectives...
Correct prognosis and staging are crucial in choosing the precise
therapy of colorectal carcinoma, probably the most universal malignancies in the USA
and Europe. As scientific technology maintains to boost swiftly, histopathology
remains an important a part of prognosis in so much malignant illnesses. during this period
of interdisciplinary drugs, the function of pathology has improved to supply
images that simply correlate with endoscopic, radiological, or operative
In this notable atlas, Tibor Tot offers colon pathology in huge
histological sections, with cross-sections of whole tumors of their anatomic
environments and their circumferential surgical margins. those distinct photos
form a advisor to analysis, tumor typing and staging in accordance with TNM standards.
They aid to evaluate the completeness of a surgical excision and to appreciate
the heterogeneity of colorectal carcinomas.
- instances illustrated in two-page spreads with medical
details, traditional histopathology, and large-section histology photos
enlarged to just about an entire web page.
- Pathology visible within the context of surrounding tissues
- The margins of malignant tumors obvious of their
- Schematic publications to interpretation of the
- Emphasis on diagnostic merits of utilizing huge
- Technical directions for acquiring large-section histopathology specimens
This atlas is the results of seven years of learning nearly 2,000 instances of colorectal
carcinoma and different intestinal lesions and is extremely advised for
pathologists, radiologists, surgeons, and oncologists alike.
Read or Download Colorectal tumors: atlas of large section histopathology PDF
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Extra info for Colorectal tumors: atlas of large section histopathology
32 Fig. 4 a Schematic guide to the morphologic details in the large section in Fig. 4. 4 Early Rectal Carcinoma, Dukes A Fig. 4 Large-section histology image of an early rectal carcinoma. 5 Early Rectal Cancer Patient data: 85-year-old man presenting with rectal bleeding. Endoscopically, a small polypoid lesion was found in the rectum, 7 cm from the anus. A preoperative diagnosis of invasive carcinoma was made on endoscopic biopsy. Surgical treatment: Rectosigmoidal resection, no preoperative irradiation.
37 2 Early Colorectal Cancer Fig. 7 Large-section histology image of an early mucinous rectal carcinoma, Dukes A. 7 demonstrates a mucinous carcinoma infiltrating the muscular layer of the rectum but respecting the outer border of the lamina muscularis propria. The tumor is classified as Dukes A according to the Dukes system and T2 according to the TNM classification. 8, is a tumor that did not infiltrate beyond the level of the lamina muscularis propria, but reached the border between the muscular layer and the pericolic tissue.
The level of the deepest invasion of the tumor and the presence or absence of metastasis are the most important prognostic factors in colorectal cancer. Tumors without metastasis and confined to the bowel wall (corresponding to stage A in Dukes’ system or to one of the categories T1 or T2 in the TNM classification) have a good prognosis and may be designated as early colorectal cancer. Thus, proper assessment of the deepest level of tumoral invasion is crucial for adequate staging of the disease.