By Wang J., MacNeil J.D., Kay J.F.
Content material: Antibiotics : teams and houses / Philip T. Reeves -- Pharmacokinetics, distribution, bioavailability, and dating to antibiotic residues / Peter Lees and Pierre-Louis Toutain -- Antibiotic residues in meals, consuming water, and meals defense rules / Kevin J. Greenlees, Lynn G. Friedlander, and Alistair Boxall -- pattern education : extraction and clean-up / Alida A.M. (Linda) Stolker and Martin Danaher -- Bioanalytical screening equipment / Sara Stead and Jacques Stark -- Chemical research : quantitative and confirmatory equipment / Jian Wang and Sherri B. Turnipseed -- unmarried residue quantitative and confirmatory equipment / Jonathan Tarbin ... [et al.] -- approach improvement and strategy validation / Jack F. Kay and James D. MacNeil -- size uncertainty / Jian Wang ... [et al.] -- caliber insurance and quality controls / Andrew Cannavan, Jack Kay, and Bruno Le Bizec
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Extra resources for Chemical Analysis of Antibiotic Residues in Food
This drug is also used in some countries to improve feed efﬁciency in pigs and chickens. Erythromycin is used for the treatment of Campylobacter enteritis and pyoderma in dogs. Although erythromycin is used in the treatment of pneumonia caused by Rhodococcus equi in foals, azithromycin combined with rifampicin is now more commonly used. As mentioned above, two pleuromutilins are used in veterinary medicine. Tiamulin is available as a pre-mix and a water-soluble powder for addition to drinking water for pigs and poultry, and as an injection for pigs.
Cyadox has been used as a feed additive for pigs, calves, and poultry to promote growth. Occupational exposure of farmworkers to the quinoxaline class of antimicrobials may result in dermal photosensitivity reactions. 4 whereby light causes a structural change in a drug so that it acts as a hapten, possibly binding to proteins in the skin. Olaquindox causes photoallergic reactions in humans and animals. On exposure to light, olaquindox forms a reactive oxaziridine derivative, and this imino-N -oxide reacts with protein to form a photoallergen.
82,83 In the case of olaquindox, the JECFA84 concluded that the substance is potentially genotoxic and that the toxicity of its metabolites is inadequately understood. For these reasons, the JECFA was unable to determine the amount of residues in food that did not cause an appreciable risk to human health, and thus MRLs were not established for these compounds by the CAC (see Chapter 3 for further discussion). Details Quinoxalines INN IUPAC Name, Molecular Formula, CAS Registry No. Carbadox Methyl (2E )-2-[(1,4-dioxidoquinoxalin-2-yl)methylene]hydrazine carboxylate Chemical Structure H3C O 6804-07-5 N N+ O− N+ N N N H Quinoxaline-1,4-dioxide C8 H6 N2 O2 2423-66-7 − O H3C HO H N O− N+ N+ author was not able to ﬁnd a pKa value for the substance in the public literature.