Catalysts for Fine Chemical Synthesis, Volume 5: Regio- and by Stanley M. Roberts, John Whittall

By Stanley M. Roberts, John Whittall

Quantity five within the Catalysts for high quality Chemical Synthesis sequence describes new systems for the regio- and stereo-controlled alterations of compounds related to oxidation or relief reactions. It describes a variety of catalysts, together with organometallic platforms, biocatalysts and biomimetics. This quantity additionally contains descriptions of various conversions, together with: Baeyer-Villiger oxidations; Epoxidation reactions; Hydroxylation reactions; Oxidation of alcohols to aldehydes, ketones and carboxylic acids; relief of ketones; and aid of alkenes together with α, β-unsaturated carbonyl compounds. The publication might be an enormous textual content for practicing artificial natural chemists in and academia.Protocols are written in a regular structure through the authors who've came upon themHints, assistance and security recommendation (where acceptable) is given to make sure that the strategies are reproducibleIndications are given as to the variety of beginning fabrics used and, the place acceptable, comparisons to substitute methodologyIncludes appropriate references to the first literature.

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By Stanley M. Roberts, John Whittall

Quantity five within the Catalysts for high quality Chemical Synthesis sequence describes new systems for the regio- and stereo-controlled alterations of compounds related to oxidation or relief reactions. It describes a variety of catalysts, together with organometallic platforms, biocatalysts and biomimetics. This quantity additionally contains descriptions of various conversions, together with: Baeyer-Villiger oxidations; Epoxidation reactions; Hydroxylation reactions; Oxidation of alcohols to aldehydes, ketones and carboxylic acids; relief of ketones; and aid of alkenes together with α, β-unsaturated carbonyl compounds. The publication might be an enormous textual content for practicing artificial natural chemists in and academia.Protocols are written in a regular structure through the authors who've came upon themHints, assistance and security recommendation (where acceptable) is given to make sure that the strategies are reproducibleIndications are given as to the variety of beginning fabrics used and, the place acceptable, comparisons to substitute methodologyIncludes appropriate references to the first literature.

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56. A. D. Enantiodivergent Biocatalytic Routes to Both Taxol Side Chain Antipodes. J. Org. Chem. 2005, 70, 9654–9657. 57. , Witholt, B. and Li, Z. Rapid Identification of New Bacterial Alcohol Dehydrogenases for (R)- and (S)-Enantioselective Reduction of b-Ketoesters. Chem. Commun. 2004, 2120–2121. 58. Matsuyama, A. Yamamoto, H. and Kobayashi, Y. Practical Application of Recombinant Whole-cell Biocatalysts for the Manufacturing of Pharmaceutical Intermediates such as Chiral Alcohols. Org. Process Res.

Org. Chem. 2005, 70, 9654–9657. 57. , Witholt, B. and Li, Z. Rapid Identification of New Bacterial Alcohol Dehydrogenases for (R)- and (S)-Enantioselective Reduction of b-Ketoesters. Chem. Commun. 2004, 2120–2121. 58. Matsuyama, A. Yamamoto, H. and Kobayashi, Y. Practical Application of Recombinant Whole-cell Biocatalysts for the Manufacturing of Pharmaceutical Intermediates such as Chiral Alcohols. Org. Process Res. Dev. 2002, 6, 558–561. 59. J. D. Process for the Preparation of Dihydroxy Esters and Derivatives.

77] describes the different methods used for this reaction and highlights the technical and environmental advantages of the transformation. Symmetrical ketones can be converted into chiral lactones that are frequently used synthons for many target molecules in modern pharmaceuticals. [78] discusses enantioselective Baeyer–Villiger oxidations by chemical and biotransformation approaches, including scope and limitations, the improvement of optical purity and implications upon scale-up. [79] High productivity was obtained by a combination of several (bio)chemical engineering techniques including resin-based in situ substrate feeding/product removal methodology, a glycerol feed control and an improved oxygenation regime.

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